Nods-like receptors in infection and immunity (NLRII)

description

​The gut flora is composed of a huge number of diverse, well-adapted symbionts that interact with epithelial lining throughout the host's entire life. Not all commensals have the same ability to maintain quiescent, protective inflammation. Importantly, instability in the composition of gut microbial communities (referred to as dysbiosis) has been linked to loss of gut barrier in the context of common human illnesses with increasing socio-economic impacts, such as malnutrition, Crohn's disease and colorectal cancer.

The composition of gut microbial communities is controlled by co-evolutionarily conserved surveillance systems, including the Nod-like receptors. Our recent findings suggest that emerging, disease-predisposing dysbiosis can now be intentionally manipulated by targeting the major Crohn's disease-predisposing NOD2 gene and the related molecule NLRP6. However, the lack of a multi-level approach with high spatial and temporal resolution biases our view of the bioactivity of the microbiota and the dynamics of the host's effector/regulatory immune network that maintain microbial symbiosis.

To address this fundamental, challenging issue, we shall seek to identify: (i) biochemical, anatomical and immunological features of commensals which overcome or preserve (either individually or as a whole organ) epithelial barrier function, and (ii) specific cellular and molecular features may shape a protective assembly of commensal lineages against intestinal inflammation and tumorigenesis. These insights will be gained by combining germ-free and Cre-LoxP technologies with innovative in vivo imaging, deep sequencing and mass spectrometry-based proteomics.

The outputs of this integrated approach may challenge dogmas on ancestral microbial-eukaryotic symbiosis, and have a broad impact on biomedical sciences worldwide.

Fields of interest

Immunology Gastroenterology Host-Microbiota interactions

Affiliations

INSERM logo CNRS logo https://www.transimmunom.org/Picture%20library/Logos/IPL.png https://www.transimmunom.org/Picture%20library/Logos/Logo_CIIL.jpg https://www.transimmunom.org/Picture%20library/Logos/U_Lille.png

CHAMAILLARD
Mathias

Team/Group
Leader

Contact info

Address: Institut Pasteur de Lille Centre d’Infection et d’Immunité de Lille Equipe 7 Nods-like receptors in infection and immunity 1, rue Professeur A Calmette
City: Lille Cedex
Postal code: 59019
Telephone: +33 3 59 31 74 27
Fax: +33 3 59 31 74 80
Email: mathias.chamaillard@inserm.fr
Website: http://u1019.lille.inserm.fr/recherche/chamaillard/

Top Publications

Cognitive Clinical Investigations

Fondamental Research